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Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

Poor metabolisers of CYP2B6 (PM) require a lower dose of efavirenz because of serious adverse reactions resulting from the higher plasma concentrations associated with a standard dose. Treatment discontinuation is a common consequence in patients experiencing these adverse reactions. Such patients b...

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Publicat a:Front Pharmacol
Autors principals: Chetty, Manoranjenni, Cain, Theresa, Wedagedera, Janak, Rostami-Hodjegan, Amin, Jamei, Masoud
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881162/
https://ncbi.nlm.nih.gov/pubmed/29636682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00247
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