Are Physiologically Based Pharmacokinetic Models Reporting the Right C(max)? Central Venous Versus Peripheral Sampling Site

Physiologically based pharmacokinetic (PBPK) models can over-predict maximum plasma concentrations (C(max)) following intravenous administration. A proposed explanation is that invariably PBPK models report the concentration in the central venous compartment, rather than the site where the samples a...

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Bibliografske podrobnosti
izdano v:AAPS J
Main Authors: Musther, Helen, Gill, Katherine L., Chetty, Manoranjenni, Rostami-Hodjegan, Amin, Rowland, Malcolm, Jamei, Masoud
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540731/
https://ncbi.nlm.nih.gov/pubmed/26100012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9796-7
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