Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence

por Rostami‐Hodjegan, Amin
Publicado en Clin Pharmacol Ther (2017)

Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate

por Rostami‐Hodjegan, Amin, Bois, Frederic Y.
Publicado en CPT Pharmacometrics Syst Pharmacol (2021)

Biosimulation in biomedical research, health care and drug development

por Mosekilde, Erik., Sosnovtseva, Olga., Rostami-Hodjegan, Amin.
Publicado 2012

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

por Tsamandouras, Nikolaos, Rostami-Hodjegan, Amin, Aarons, Leon
Publicado en Br J Clin Pharmacol (2015)

Precision medicine technology hype or reality? The example of computer-guided dosing

por Polasek, Thomas M., Shakib, Sepehr, Rostami-Hodjegan, Amin
Publicado en F1000Res (2019)

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

por Scotcher, Daniel, Jones, Christopher, Rostami-Hodjegan, Amin, Galetin, Aleksandra
Publicado en Eur J Pharm Sci (2016)

Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic M...

por Doki, Kosuke, Neuhoff, Sibylle, Rostami‐Hodjegan, Amin, Homma, Masato
Publicado en CPT Pharmacometrics Syst Pharmacol (2019)

Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

por Takita, Hiroyuki, Darwich, Adam S., Ahmad, Amais, Rostami‐Hodjegan, Amin
Publicado en CPT Pharmacometrics Syst Pharmacol (2020)

The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies –CYP2C9 and warfarin as an example

por Dickinson, Gemma L, Lennard, Martin S, Tucker, Geoffrey T, Rostami-Hodjegan, Amin
Publicado 2007

Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model

por Abduljalil, Khaled, Jamei, Masoud, Rostami-Hodjegan, Amin, Johnson, Trevor N.
Publicado 2014

Choice of LC-MS Methods for the Absolute Quantification of Drug-Metabolizing Enzymes and Transporters in Human Tissue: a Comparative Cost Analysis

por Al Feteisi, Hajar, Achour, Brahim, Barber, Jill, Rostami-Hodjegan, Amin
Publicado en AAPS J (2015)

Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug...

por Olivares-Morales, Andrés, Lennernäs, Hans, Aarons, Leon, Rostami-Hodjegan, Amin
Publicado en AAPS J (2015)

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

por Scotcher, Daniel, Jones, Christopher R., Galetin, Aleksandra, Rostami-Hodjegan, Amin
Publicado en J Pharmacol Exp Ther (2017)

Precision dosing to avoid adverse drug reactions

por Polasek, Thomas M., Kirkpatrick, Carl M. J., Rostami-Hodjegan, Amin
Publicado en Ther Adv Drug Saf (2019)

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

por Margolskee, Alison, Darwich, Adam S., Galetin, Aleksandra, Rostami-Hodjegan, Amin, Aarons, Leon
Publicado en AAPS J (2015)

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

por Chetty, Manoranjenni, Cain, Theresa, Wedagedera, Janak, Rostami-Hodjegan, Amin, Jamei, Masoud
Publicado en Front Pharmacol (2018)

A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4

por Gaohua, Lu, Abduljalil, Khaled, Jamei, Masoud, Johnson, Trevor N, Rostami-Hodjegan, Amin
Publicado 2012

Quantifying gut wall metabolism: methodology matters

por Hatley, Oliver J.D., Jones, Christopher R., Galetin, Aleksandra, Rostami‐Hodjegan, Amin
Publicado en Biopharm Drug Dispos (2017)

Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors

por Hatley, Oliver J.D., Jones, Christopher R., Galetin, Aleksandra, Rostami‐Hodjegan, Amin
Publicado en Biopharm Drug Dispos (2017)

Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models

por Liu, Dan, Li, Linzhong, Rostami-Hodjegan, Amin, Bois, Frederic Y., Jamei, Masoud
Publicado en AAPS J (2020)