A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4

AIMS: Pregnant women are usually not part of the traditional drug development programme. Pregnancy is associated with major biological and physiological changes that alter the pharmacokinetics (PK) of drugs. Prediction of the changes to drug exposure in this group of patients may help to prevent und...

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Detalhes bibliográficos
Main Authors: Gaohua, Lu, Abduljalil, Khaled, Jamei, Masoud, Johnson, Trevor N, Rostami-Hodjegan, Amin
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Drugs in Pregnancy and Lactation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495152/
https://ncbi.nlm.nih.gov/pubmed/22725721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04363.x
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