Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling

Plasma concentrations of dabigatran, an active principle of prodrug dabigatran etexilate (DABE), are increased by renal impairment (RI) or coadministration of a P‐glycoprotein inhibitor. Because the combined effects of drug–drug interactions and RI have not been evaluated by means of clinical studie...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:CPT Pharmacometrics Syst Pharmacol
Main Authors: Doki, Kosuke, Neuhoff, Sibylle, Rostami‐Hodjegan, Amin, Homma, Masato
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389344/
https://ncbi.nlm.nih.gov/pubmed/30659778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12382
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki