Physiologically based pharmacokinetic model for 6-mercpatopurine: exploring the role of genetic polymorphism in TPMT enzyme activity

Por Ogungbenro, Kayode, Aarons, Leon
Publicado no Br J Clin Pharmacol (2015)

COST B15: modelling in drug development

Por Aarons, Leon, Balant, Luc, Boobis, Alan
Publicado em 2001

Empirical and Semi-Mechanistic Modelling of Double-Peaked Pharmacokinetic Profile Phenomenon Due to Gastric Emptying

Por Ogungbenro, Kayode, Pertinez, Henry, Aarons, Leon
Publicado no AAPS J (2014)

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

Por Tsamandouras, Nikolaos, Rostami-Hodjegan, Amin, Aarons, Leon
Publicado no Br J Clin Pharmacol (2015)

Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression

Por Martin, Emma C., Aarons, Leon, Yates, James W. T.
Publicado no Toxicol Sci (2016)

Predicting survival of pancreatic cancer patients treated with gemcitabine using longitudinal tumour size data

Por Wendling, Thierry, Mistry, Hitesh, Ogungbenro, Kayode, Aarons, Leon
Publicado no Cancer Chemother Pharmacol (2016)

Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

Por Martin, Emma C., Aarons, Leon, Yates, James W. T.
Publicado no Cancer Chemother Pharmacol (2016)

Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug...

Por Olivares-Morales, Andrés, Lennernäs, Hans, Aarons, Leon, Rostami-Hodjegan, Amin
Publicado no AAPS J (2015)

Use of Nonlinear Mixed-Effects Analysis for Improved Precision of Early Pharmacodynamic Measures in Tuberculosis Treatment

Por Davies, Geraint R., Brindle, Richard, Khoo, Saye H., Aarons, Leon J.
Publicado em 2006

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

Por Margolskee, Alison, Darwich, Adam S., Galetin, Aleksandra, Rostami-Hodjegan, Amin, Aarons, Leon
Publicado no AAPS J (2015)

Population pharmacokinetics and optimal design of paediatric studies for famciclovir

Por Ogungbenro, Kayode, Matthews, Ivan, Looby, Michael, Kaiser, Guenther, Graham, Gordon, Aarons, Leon
Publicado em 2009

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results

Por Chenel, Marylore, Bouzom, François, Cazade, Fanny, Ogungbenro, Kayode, Aarons, Leon, Mentré, France
Publicado em 2008

Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data

Por Wendling, Thierry, Tsamandouras, Nikolaos, Dumitras, Swati, Pigeolet, Etienne, Ogungbenro, Kayode, Aarons, Leon
Publicado no AAPS J (2015)

Retrospective population pharmacokinetic analysis of cetirizine in children aged 6 months to 12 years

Por Pitsiu, Maria, Hussein, Ziad, Majid, Oneeb, Aarons, Leon, de Longueville, Marc, Stockis, Armel
Publicado em 2004

Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: the ETAC® study

Por Hussein, Ziad, Pitsiu, Maria, Majid, Oneeb, Aarons, Leon, de Longueville, Marc, Stockis, Armel
Publicado em 2005

Population pharmacokinetics of the MEK inhibitor selumetinib and its active N‐desmethyl metabolite: data from 10 phase I trials

Por Patel, Parul, Howgate, Eleanor, Martin, Paul, Carlile, David J., Aarons, Leon, Zhou, Diansong
Publicado no Br J Clin Pharmacol (2017)

The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

Por Olivares-Morales, Andrés, Hatley, Oliver J. D., Turner, David, Galetin, Aleksandra, Aarons, Leon, Rostami-Hodjegan, Amin
Publicado no Pharm Res (2013)

Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance

Por Simpson, Julie A., Watkins, Emmeline R., Price, Ric N., Aarons, Leon, Kyle, Dennis E., White, Nicholas J.
Publicado em 2000

Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers

Por Dickinson, Laura, Boffito, Marta, Back, David, Waters, Laura, Else, Laura, Davies, Geraint, Khoo, Saye, Pozniak, Anton, Aarons, Leon
Publicado em 2009

Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing

Por Dickinson, Laura, Boffito, Marta, Khoo, Saye H., Schutz, Malte, Aarons, Leon J., Pozniak, Anton L., Back, David J.
Publicado em 2008