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Empirical and Semi-Mechanistic Modelling of Double-Peaked Pharmacokinetic Profile Phenomenon Due to Gastric Emptying

Models have been developed to explain double-peaked plasma concentration-time profiles using mechanisms such as variable absorption and enterohepatic recirculation. Interruption of gastric emptying has also been shown to produce double-peaks, and this work proposes models for analysis of such data....

詳細記述

保存先:
書誌詳細
出版年:AAPS J
主要な著者: Ogungbenro, Kayode, Pertinez, Henry, Aarons, Leon
フォーマット: Artigo
言語:Inglês
出版事項: Springer US 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287295/
https://ncbi.nlm.nih.gov/pubmed/25413723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9693-5
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