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Choice of LC-MS Methods for the Absolute Quantification of Drug-Metabolizing Enzymes and Transporters in Human Tissue: a Comparative Cost Analysis

The quantification of drug-metabolizing enzymes and transporters is important for in vitro-in vivo extrapolation (IVIVE) of xenobiotic clearance, which has become an integral part of drug development. There are different mass spectrometry-based techniques used for quantitative proteomics, and as mor...

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Bibliografiska uppgifter
I publikationen:AAPS J
Huvudupphovsmän: Al Feteisi, Hajar, Achour, Brahim, Barber, Jill, Rostami-Hodjegan, Amin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer US 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365102/
https://ncbi.nlm.nih.gov/pubmed/25663651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9712-6
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