Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine

The levels of drug-metabolizing enzymes (DMEs) and transporter proteins in the human intestine are pertinent to determine oral drug bioavailability. Despite the paucity of reports on such measurements, it is well recognized that these values are essential for translating in vitro data on drug metabo...

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Publicado en:Drug Metab Dispos
Autores principales: Couto, Narciso, Al-Majdoub, Zubida M., Gibson, Stephanie, Davies, Pamela J., Achour, Brahim, Harwood, Matthew D., Carlson, Gordon, Barber, Jill, Rostami-Hodjegan, Amin, Warhurst, Geoffrey
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076527/
https://ncbi.nlm.nih.gov/pubmed/31959703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.089656
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