Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine

The levels of drug-metabolizing enzymes (DMEs) and transporter proteins in the human intestine are pertinent to determine oral drug bioavailability. Despite the paucity of reports on such measurements, it is well recognized that these values are essential for translating in vitro data on drug metabo...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Couto, Narciso, Al-Majdoub, Zubida M., Gibson, Stephanie, Davies, Pamela J., Achour, Brahim, Harwood, Matthew D., Carlson, Gordon, Barber, Jill, Rostami-Hodjegan, Amin, Warhurst, Geoffrey
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076527/
https://ncbi.nlm.nih.gov/pubmed/31959703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.089656
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