Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Although advantages of physiologically based pharmacokinetic models (PBPK) are now well established, PBPK models that are linked to pharmacodynamic (PD) models to predict pharmacokinetics (PK), PD, and efficacy of monoclonal antibodies (mAbs) in humans are uncommon. The aim of this study was to deve...

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Publicat a:Front Immunol
Autors principals: Chetty, Manoranjenni, Li, Linzhong, Rose, Rachel, Machavaram, Krishna, Jamei, Masoud, Rostami-Hodjegan, Amin, Gardner, Iain
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283607/
https://ncbi.nlm.nih.gov/pubmed/25601866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00670
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