Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Although advantages of physiologically based pharmacokinetic models (PBPK) are now well established, PBPK models that are linked to pharmacodynamic (PD) models to predict pharmacokinetics (PK), PD, and efficacy of monoclonal antibodies (mAbs) in humans are uncommon. The aim of this study was to deve...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Chetty, Manoranjenni, Li, Linzhong, Rose, Rachel, Machavaram, Krishna, Jamei, Masoud, Rostami-Hodjegan, Amin, Gardner, Iain
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2015
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283607/
https://ncbi.nlm.nih.gov/pubmed/25601866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00670
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