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Simulation of Monoclonal Antibody Pharmacokinetics in HumansUsing a Minimal Physiologically Based Model

Compared to small chemical molecules, monoclonal antibodies and Fc-containing derivatives (mAbs) have unique pharmacokinetic behaviour characterised by relatively poor cellular permeability, minimal renal filtration, binding to FcRn, target-mediated drug disposition, and disposition via lymph. A min...

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Bibliografiske detaljer
Main Authors: Li, Linzhong, Gardner, Iain, Dostalek, Miroslav, Jamei, Masoud
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147043/
https://ncbi.nlm.nih.gov/pubmed/25004823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9640-5
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