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A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

The ability to predict subcutaneous (SC) absorption rate and tissue distribution of therapeutic proteins (TPs) using a bottom-up approach is highly desirable early in the drug development process prior to clinical data being available. A whole-body physiologically based pharmacokinetic (PBPK) model,...

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Publicat a:AAPS J
Autors principals: Gill, Katherine L., Gardner, Iain, Li, Linzhong, Jamei, Masoud
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890583/
https://ncbi.nlm.nih.gov/pubmed/26408308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9819-4
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