Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Although advantages of physiologically based pharmacokinetic models (PBPK) are now well established, PBPK models that are linked to pharmacodynamic (PD) models to predict pharmacokinetics (PK), PD, and efficacy of monoclonal antibodies (mAbs) in humans are uncommon. The aim of this study was to deve...

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Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Chetty, Manoranjenni, Li, Linzhong, Rose, Rachel, Machavaram, Krishna, Jamei, Masoud, Rostami-Hodjegan, Amin, Gardner, Iain
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2015
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283607/
https://ncbi.nlm.nih.gov/pubmed/25601866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00670
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