Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability

This study aimed to demonstrate the added value of integrating prior in vitro data and knowledge-rich physiologically based pharmacokinetic (PBPK) models with pharmacodynamics (PDs) models. Four distinct applications that were developed and tested are presented here. PBPK models were developed for m...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Chetty, Manoranjenni, Rose, Rachel H., Abduljalil, Khaled, Patel, Nikunjkumar, Lu, Gaohua, Cain, Theresa, Jamei, Masoud, Rostami-Hodjegan, Amin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244809/
https://ncbi.nlm.nih.gov/pubmed/25505415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00258
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados