Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1-Related Variability in Pharmacodynamics of Rosuvastatin

Typically, pharmacokinetic–pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in uptake transporter activity can lead to variable drug concentrations in plasma without discernible impact on the effect site organ concent...

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Detalhes bibliográficos
Main Authors: Rose, R H, Neuhoff, S, Abduljalil, K, Chetty, M, Rostami-Hodjegan, A, Jamei, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120018/
https://ncbi.nlm.nih.gov/pubmed/25006781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2014.24
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