Review: Improving the Therapeutic Index of 8-Aminoquinolines by the Use of Drug Combinations: Review of the Literature and Proposal for Future Investigations

Bằng Myint, Hla Y., Berman, Jonathan, Walker, Larry, Pybus, Brandon, Melendez, Victor, Baird, J. Kevin, Ohrt, Colin
Được phát hành 2011

Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

Bằng Kraut, Daniel A, Sigala, Paul A, Pybus, Brandon, Liu, Corey W, Ringe, Dagmar, Petsko, Gregory A, Herschlag, Daniel
Được phát hành 2006

Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections

Bằng Li, Qigui, O’Neil, Michael, Xie, Lisa, Caridha, Diana, Zeng, Qiang, Zhang, Jing, Pybus, Brandon, Hickman, Mark, Melendez, Victor
Được phát hành 2014

Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

Bằng Sigala, Paul A., Kraut, Daniel A., Caaveiro, Jose M. M., Pybus, Brandon, Ruben, Eliza A., Ringe, Dagmar, Petsko, Gregory A., Herschlag, Daniel
Được phát hành 2008

Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site

Bằng Sigala, Paul A., Fafarman, Aaron T., Schwans, Jason P., Fried, Stephen D., Fenn, Timothy D., Caaveiro, Jose M. M., Pybus, Brandon, Ringe, Dagmar, Petsko, Gregory A., Boxer, Steven G., Herschlag, Daniel
Được phát hành 2013

CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

Bằng Marcsisin, Sean R, Jin, Xiannu, Bettger, Theresa, McCulley, Nicholas, Sousa, Jason C, Shanks, G Dennis, Tekwani, Babu L, Sahu, Rajnish, Reichard, Gregory A, Sciotti, Richard J, Melendez, Victor, Pybus, Brandon S
Được phát hành 2013

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

Bằng Pybus, Brandon S, Marcsisin, Sean R, Jin, Xiannu, Deye, Gregory, Sousa, Jason C, Li, Qigui, Caridha, Diana, Zeng, Qiang, Reichard, Gregory A, Ockenhouse, Christian, Bennett, Jason, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Được phát hành 2013

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

Bằng Pybus Brandon S, Sousa Jason C, Jin Xiannu, Ferguson James A, Christian Robert E, Barnhart Rebecca, Vuong Chau, Sciotti Richard J, Reichard Gregory A, Kozar Michael P, Walker Larry A, Ohrt Colin, Melendez Victor
Được phát hành 2012-08-01

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

Bằng Pybus, Brandon S, Sousa, Jason C, Jin, Xiannu, Ferguson, James A, Christian, Robert E, Barnhart, Rebecca, Vuong, Chau, Sciotti, Richard J, Reichard, Gregory A, Kozar, Michael P, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Được phát hành 2012

Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants

Bằng Jin, Xiannu, Potter, Brittney, Luong, Thu-lan, Nelson, Jennifer, Vuong, Chau, Potter, Corttney, Xie, Lisa, Zhang, Jing, Zhang, Ping, Sousa, Jason, Li, Qigui, Pybus, Brandon S., Kreishman-Deitrick, Mara, Hickman, Mark, Smith, Philip L., Paris, Robert, Reichard, Gregory, Marcsisin, Sean R.
Xuất bản năm Malar J (2016)

The fibrinolytic system enables the onset of Plasmodium infection in the mosquito vector and the mammalian host

Bằng Alves e Silva, Thiago Luiz, Radtke, Andrea, Balaban, Amanda, Pascini, Tales Vicari, Pala, Zarna Rajeshkumar, Roth, Alison, Alvarenga, Patricia H., Jeong, Yeong Je, Olivas, Janet, Ghosh, Anil K., Bui, Hanhvy, Pybus, Brandon S., Sinnis, Photini, Jacobs-Lorena, Marcelo, Vega-Rodríguez, Joel
Xuất bản năm Sci Adv (2021)

Enantioselective metabolism of primaquine by human CYP2D6

Bằng Fasinu, Pius S, Tekwani, Babu L, Nanayakkara, NP Dhammika, Avula, Bharathi, Herath, HMT Bandara, Wang, Yan-Hong, Adelli, Vijender R, Elsohly, Mahmoud A, Khan, Shabana I, Khan, Ikhlas A, Pybus, Brandon S, Marcsisin, Sean R, Reichard, Gregory A, McChesney, James D, Walker, Larry A
Xuất bản năm Malar J (2014)

Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques

Bằng Vanachayangkul, Pattaraporn, Im-erbsin, Rawiwan, Tungtaeng, Anchalee, Kodchakorn, Chanikarn, Roth, Alison, Adams, John, Chaisatit, Chaiyaporn, Saingam, Piyaporn, Sciotti, Richard J., Reichard, Gregory A., Nolan, Christina K., Pybus, Brandon S., Black, Chad C., Lugo-Roman, Luis A., Wegner, Matthew D., Smith, Philip L., Wojnarski, Mariusz, Vesely, Brian A., Kobylinski, Kevin C.
Xuất bản năm Antimicrob Agents Chemother (2020)

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

Bằng Marcsisin, Sean R, Sousa, Jason C, Reichard, Gregory A, Caridha, Diana, Zeng, Qiang, Roncal, Norma, McNulty, Ronan, Careagabarja, Julio, Sciotti, Richard J, Bennett, Jason W, Zottig, Victor E, Deye, Gregory, Li, Qigui, Read, Lisa, Hickman, Mark, Nanayakkara, N P Dhammika, Walker, Larry A, Smith, Bryan, Melendez, Victor, Pybus, Brandon S
Được phát hành 2014

Differential Cytochrome P450 2D Metabolism Alters Tafenoquine Pharmacokinetics

Bằng Vuong, Chau, Xie, Lisa H., Potter, Brittney M. J., Zhang, Jing, Zhang, Ping, Duan, Dehui, Nolan, Christina K., Sciotti, Richard J., Zottig, Victor E., Nanayakkara, N. P. Dhammika, Tekwani, Babu L., Walker, Larry A., Smith, Philip L., Paris, Robert M., Read, Lisa T., Li, Qigui, Pybus, Brandon S., Sousa, Jason C., Reichard, Gregory A., Smith, Bryan, Marcsisin, Sean R.
Xuất bản năm Antimicrob Agents Chemother (2015)

Corrigendum to: Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population

Bằng Spring, Michele D, Sousa, Jason C, Li, Qigui, Darko, Christian A, Morrison, Meshell N, Marcsisin, Sean R, Mills, Kristin T, Potter, Brittney M, Paolino, Kristopher M, Twomey, Patrick S, Moon, James E, Tosh, Donna M, Cicatelli, Susan B, Froude, Jeffrey W, Pybus, Brandon S, Oliver, Thomas G, Mccarthy, William F, Waters, Norman C, Smith, Philip L, Reichard, Gregory A, Bennett, Jason W
Xuất bản năm J Infect Dis (2020)

Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

Bằng Potter, Brittney M. J., Xie, Lisa H., Vuong, Chau, Zhang, Jing, Zhang, Ping, Duan, Dehui, Luong, Thu-Lan T., Bandara Herath, H. M. T., Dhammika Nanayakkara, N. P., Tekwani, Babu L., Walker, Larry A., Nolan, Christina K., Sciotti, Richard J., Zottig, Victor E., Smith, Philip L., Paris, Robert M., Read, Lisa T., Li, Qigui, Pybus, Brandon S., Sousa, Jason C., Reichard, Gregory A., Marcsisin, Sean R.
Xuất bản năm Antimicrob Agents Chemother (2015)

Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population

Bằng Spring, Michele D, Sousa, Jason C, Li, Qigui, Darko, Christian A, Morrison, Meshell N, Marcsisin, Sean R, Mills, Kristin T, Potter, Brittney M, Paolino, Kristopher M, Twomey, Patrick S, Moon, James E, Tosh, Donna M, Cicatelli, Susan B, Froude, Jeffrey W, Pybus, Brandon S, Oliver, Thomas G, McCarthy, William F, Waters, Norman C, Smith, Philip L, Reichard, Gregory A, Bennett, Jason W
Xuất bản năm J Infect Dis (2019)

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials

Bằng Kancharla, Papireddy, Dodean, Rozalia A., Li, Yuexin, Pou, Sovitj, Pybus, Brandon, Melendez, Victor, Read, Lisa, Bane, Charles E., Vesely, Brian, Kreishman-Deitrick, Mara, Black, Chad, Li, Qigui, Sciotti, Richard J., Olmeda, Raul, Luong, Thu-Lan, Gaona, Heather, Potter, Brittney, Sousa, Jason, Marcsisin, Sean, Caridha, Diana, Xie, Lisa, Vuong, Chau, Zeng, Qiang, Zhang, Jing, Zhang, Ping, Lin, Hsiuling, Butler, Kirk, Roncal, Norma, Gaynor-Ohnstad, Lacy, Leed, Susan E., Nolan, Christina, Ceja, Frida G., Rasmussen, Stephanie A., Tumwebaze, Patrick K., Rosenthal, Philip J., Mu, Jianbing, Bayles, Brett R., Cooper, Roland A., Reynolds, Kevin A., Smilkstein, Martin J., Riscoe, Michael K., Kelly, Jane X.
Xuất bản năm J Med Chem (2020)

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases

Bằng Nagle, Advait, Biggart, Agnes, Be, Celine, Srinivas, Honnappa, Hein, Andreas, Caridha, Diana, Sciotti, Richard J., Pybus, Brandon, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin H., Gao, Mu-Yun, Liang, Fang, Mathison, Casey J. N., Liu, Xiaodong, Yeh, Vince, Smith, Jeffrey, Lerario, Isabelle, Xie, Yongping, Chianelli, Donatella, Gibney, Michael, Berman, Ashley, Chen, Yen-Liang, Jiricek, Jan, Davis, Lauren C., Liu, Xianzhong, Ballard, Jaime, Khare, Shilpi, Eggimann, Fabian Kurt, Luneau, Alexandre, Groessl, Todd, Shapiro, Michael, Richmond, Wendy, Johnson, Kevin, Rudewicz, Patrick J., Rao, Srinivasa P. S., Thompson, Christopher, Tuntland, Tove, Spraggon, Glen, Glynne, Richard J., Supek, Frantisek, Wiesmann, Christian, Molteni, Valentina
Xuất bản năm J Med Chem (2020)