Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs

par Wickham, Kristina S., Baresel, Paul C., Marcsisin, Sean R., Sousa, Jason, Vuong, Chau T., Reichard, Gregory A., Campo, Brice, Tekwani, Babu L., Walker, Larry A., Rochford, Rosemary
Publié dans Antimicrob Agents Chemother (2016)

CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

par Marcsisin, Sean R, Jin, Xiannu, Bettger, Theresa, McCulley, Nicholas, Sousa, Jason C, Shanks, G Dennis, Tekwani, Babu L, Sahu, Rajnish, Reichard, Gregory A, Sciotti, Richard J, Melendez, Victor, Pybus, Brandon S
Publié 2013

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

par Pybus, Brandon S, Marcsisin, Sean R, Jin, Xiannu, Deye, Gregory, Sousa, Jason C, Li, Qigui, Caridha, Diana, Zeng, Qiang, Reichard, Gregory A, Ockenhouse, Christian, Bennett, Jason, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Publié 2013

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

par Pybus Brandon S, Sousa Jason C, Jin Xiannu, Ferguson James A, Christian Robert E, Barnhart Rebecca, Vuong Chau, Sciotti Richard J, Reichard Gregory A, Kozar Michael P, Walker Larry A, Ohrt Colin, Melendez Victor
Publié 2012-08-01

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

par Pybus, Brandon S, Sousa, Jason C, Jin, Xiannu, Ferguson, James A, Christian, Robert E, Barnhart, Rebecca, Vuong, Chau, Sciotti, Richard J, Reichard, Gregory A, Kozar, Michael P, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Publié 2012

Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes

par Fasinu, Pius S., Avula, Bharathi, Tekwani, Babu L., Nanayakkara, N. P. Dhammika, Wang, Yan-Hong, Bandara Herath, H. M. T., McChesney, James D., Reichard, Gregory A., Marcsisin, Sean R., Elsohly, Mahmoud A., Khan, Shabana I., Khan, Ikhlas A., Walker, Larry A.
Publié dans Malar J (2016)

Enantioselective metabolism of primaquine by human CYP2D6

par Fasinu, Pius S, Tekwani, Babu L, Nanayakkara, NP Dhammika, Avula, Bharathi, Herath, HMT Bandara, Wang, Yan-Hong, Adelli, Vijender R, Elsohly, Mahmoud A, Khan, Shabana I, Khan, Ikhlas A, Pybus, Brandon S, Marcsisin, Sean R, Reichard, Gregory A, McChesney, James D, Walker, Larry A
Publié dans Malar J (2014)

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers

par Nanayakkara, N. P. Dhammika, Tekwani, Babu L., Herath, H. M. T. Bandara, Sahu, Rajnish, Gettayacamin, Montip, Tungtaeng, Anchalee, van Gessel, Yvonne, Baresel, Paul, Wickham, Kristina S., Bartlett, Marilyn S., Fronczek, Frank R., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., McChesney, James D., Rochford, Rosemary, Walker, Larry A.
Publié 2014

Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques

par Vanachayangkul, Pattaraporn, Im-erbsin, Rawiwan, Tungtaeng, Anchalee, Kodchakorn, Chanikarn, Roth, Alison, Adams, John, Chaisatit, Chaiyaporn, Saingam, Piyaporn, Sciotti, Richard J., Reichard, Gregory A., Nolan, Christina K., Pybus, Brandon S., Black, Chad C., Lugo-Roman, Luis A., Wegner, Matthew D., Smith, Philip L., Wojnarski, Mariusz, Vesely, Brian A., Kobylinski, Kevin C.
Publié dans Antimicrob Agents Chemother (2020)

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

par Marcsisin, Sean R, Sousa, Jason C, Reichard, Gregory A, Caridha, Diana, Zeng, Qiang, Roncal, Norma, McNulty, Ronan, Careagabarja, Julio, Sciotti, Richard J, Bennett, Jason W, Zottig, Victor E, Deye, Gregory, Li, Qigui, Read, Lisa, Hickman, Mark, Nanayakkara, N P Dhammika, Walker, Larry A, Smith, Bryan, Melendez, Victor, Pybus, Brandon S
Publié 2014

Differential Cytochrome P450 2D Metabolism Alters Tafenoquine Pharmacokinetics

par Vuong, Chau, Xie, Lisa H., Potter, Brittney M. J., Zhang, Jing, Zhang, Ping, Duan, Dehui, Nolan, Christina K., Sciotti, Richard J., Zottig, Victor E., Nanayakkara, N. P. Dhammika, Tekwani, Babu L., Walker, Larry A., Smith, Philip L., Paris, Robert M., Read, Lisa T., Li, Qigui, Pybus, Brandon S., Sousa, Jason C., Reichard, Gregory A., Smith, Bryan, Marcsisin, Sean R.
Publié dans Antimicrob Agents Chemother (2015)

Corrigendum to: Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population

par Spring, Michele D, Sousa, Jason C, Li, Qigui, Darko, Christian A, Morrison, Meshell N, Marcsisin, Sean R, Mills, Kristin T, Potter, Brittney M, Paolino, Kristopher M, Twomey, Patrick S, Moon, James E, Tosh, Donna M, Cicatelli, Susan B, Froude, Jeffrey W, Pybus, Brandon S, Oliver, Thomas G, Mccarthy, William F, Waters, Norman C, Smith, Philip L, Reichard, Gregory A, Bennett, Jason W
Publié dans J Infect Dis (2020)

Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

par Potter, Brittney M. J., Xie, Lisa H., Vuong, Chau, Zhang, Jing, Zhang, Ping, Duan, Dehui, Luong, Thu-Lan T., Bandara Herath, H. M. T., Dhammika Nanayakkara, N. P., Tekwani, Babu L., Walker, Larry A., Nolan, Christina K., Sciotti, Richard J., Zottig, Victor E., Smith, Philip L., Paris, Robert M., Read, Lisa T., Li, Qigui, Pybus, Brandon S., Sousa, Jason C., Reichard, Gregory A., Marcsisin, Sean R.
Publié dans Antimicrob Agents Chemother (2015)

Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population

par Spring, Michele D, Sousa, Jason C, Li, Qigui, Darko, Christian A, Morrison, Meshell N, Marcsisin, Sean R, Mills, Kristin T, Potter, Brittney M, Paolino, Kristopher M, Twomey, Patrick S, Moon, James E, Tosh, Donna M, Cicatelli, Susan B, Froude, Jeffrey W, Pybus, Brandon S, Oliver, Thomas G, McCarthy, William F, Waters, Norman C, Smith, Philip L, Reichard, Gregory A, Bennett, Jason W
Publié dans J Infect Dis (2019)