Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs

Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) are at risk for developing hemolytic anemia when given the antimalarial drug primaquine (PQ). The WHO Evidence Review Group released a report suggesting that mass administration of a single dose of PQ at 0.25 mg of base/kg...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wickham, Kristina S., Baresel, Paul C., Marcsisin, Sean R., Sousa, Jason, Vuong, Chau T., Reichard, Gregory A., Campo, Brice, Tekwani, Babu L., Walker, Larry A., Rochford, Rosemary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038314/
https://ncbi.nlm.nih.gov/pubmed/27458212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00600-16
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