Pharmacokinetics and Pharmacodynamics of (+)-Primaquine and (−)-Primaquine Enantiomers in Rhesus Macaques (Macaca mulatta)

Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure. While this drug was administered as a racemic mixture, prior studies suggested a pharmacodynamic advantage based on differential antirelapse activity and/or toxicities o...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Saunders, David, Vanachayangkul, Pattaraporn, Imerbsin, Rawiwan, Khemawoot, Phisit, Siripokasupkul, Raveewan, Tekwani, Babu L., Sampath, Aruna, Nanayakkara, N. P. Dhammika, Ohrt, Colin, Lanteri, Charlotte, Gettyacamin, Montip, Teja-Isavadharm, Paktiya, Walker, Larry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249570/
https://ncbi.nlm.nih.gov/pubmed/25267666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02576-13
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