Pharmacokinetics and Pharmacodynamics of (+)-Primaquine and (−)-Primaquine Enantiomers in Rhesus Macaques (Macaca mulatta)

Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure. While this drug was administered as a racemic mixture, prior studies suggested a pharmacodynamic advantage based on differential antirelapse activity and/or toxicities o...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Saunders, David, Vanachayangkul, Pattaraporn, Imerbsin, Rawiwan, Khemawoot, Phisit, Siripokasupkul, Raveewan, Tekwani, Babu L., Sampath, Aruna, Nanayakkara, N. P. Dhammika, Ohrt, Colin, Lanteri, Charlotte, Gettyacamin, Montip, Teja-Isavadharm, Paktiya, Walker, Larry
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249570/
https://ncbi.nlm.nih.gov/pubmed/25267666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02576-13
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