Pharmacokinetics and Pharmacodynamics of (+)-Primaquine and (−)-Primaquine Enantiomers in Rhesus Macaques (Macaca mulatta)

Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure. While this drug was administered as a racemic mixture, prior studies suggested a pharmacodynamic advantage based on differential antirelapse activity and/or toxicities o...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Saunders, David, Vanachayangkul, Pattaraporn, Imerbsin, Rawiwan, Khemawoot, Phisit, Siripokasupkul, Raveewan, Tekwani, Babu L., Sampath, Aruna, Nanayakkara, N. P. Dhammika, Ohrt, Colin, Lanteri, Charlotte, Gettyacamin, Montip, Teja-Isavadharm, Paktiya, Walker, Larry
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2014
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249570/
https://ncbi.nlm.nih.gov/pubmed/25267666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02576-13
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