Pharmacokinetics and Pharmacodynamics of (+)-Primaquine and (−)-Primaquine Enantiomers in Rhesus Macaques (Macaca mulatta)

Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure. While this drug was administered as a racemic mixture, prior studies suggested a pharmacodynamic advantage based on differential antirelapse activity and/or toxicities o...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Saunders, David, Vanachayangkul, Pattaraporn, Imerbsin, Rawiwan, Khemawoot, Phisit, Siripokasupkul, Raveewan, Tekwani, Babu L., Sampath, Aruna, Nanayakkara, N. P. Dhammika, Ohrt, Colin, Lanteri, Charlotte, Gettyacamin, Montip, Teja-Isavadharm, Paktiya, Walker, Larry
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249570/
https://ncbi.nlm.nih.gov/pubmed/25267666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02576-13
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