Absolute Bioavailability of cis-Mirincamycin and trans-Mirincamycin in Healthy Rhesus Monkeys and Ex Vivo Antimalarial Activity against Plasmodium falciparum

The pharmacokinetics, oral bioavailability, and ex vivo antimalarial activity of mirincamycin isomers in a healthy rhesus monkey model were assessed to support lead optimization of novel nonhemolytic drugs for radical cure and causal prophylaxis of malaria. Fourteen male rhesus monkeys were randomiz...

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Detalhes bibliográficos
Main Authors: Khemawoot, Phisit, Saunders, David, Rasameesoraj, Maneerat, Melendez, Victor, Imerbsin, Rawiwan, Ohrt, Colin, Fracisco, Susan, Teja-isavadharm, Paktiya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232806/
https://ncbi.nlm.nih.gov/pubmed/21947400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01619-10
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