Pharmacokinetics and Pharmacodynamics of (+)-Primaquine and (−)-Primaquine Enantiomers in Rhesus Macaques (Macaca mulatta)

Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure. While this drug was administered as a racemic mixture, prior studies suggested a pharmacodynamic advantage based on differential antirelapse activity and/or toxicities o...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Saunders, David, Vanachayangkul, Pattaraporn, Imerbsin, Rawiwan, Khemawoot, Phisit, Siripokasupkul, Raveewan, Tekwani, Babu L., Sampath, Aruna, Nanayakkara, N. P. Dhammika, Ohrt, Colin, Lanteri, Charlotte, Gettyacamin, Montip, Teja-Isavadharm, Paktiya, Walker, Larry
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249570/
https://ncbi.nlm.nih.gov/pubmed/25267666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02576-13
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