Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers

Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria. PQ is currently clinically used in its racemic form. A...

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Autori principali: Nanayakkara, N. P. Dhammika, Tekwani, Babu L., Herath, H. M. T. Bandara, Sahu, Rajnish, Gettayacamin, Montip, Tungtaeng, Anchalee, van Gessel, Yvonne, Baresel, Paul, Wickham, Kristina S., Bartlett, Marilyn S., Fronczek, Frank R., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., McChesney, James D., Rochford, Rosemary, Walker, Larry A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136050/
https://ncbi.nlm.nih.gov/pubmed/24913163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02674-13
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