Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers

Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria. PQ is currently clinically used in its racemic form. A...

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Detaylı Bibliyografya
Asıl Yazarlar: Nanayakkara, N. P. Dhammika, Tekwani, Babu L., Herath, H. M. T. Bandara, Sahu, Rajnish, Gettayacamin, Montip, Tungtaeng, Anchalee, van Gessel, Yvonne, Baresel, Paul, Wickham, Kristina S., Bartlett, Marilyn S., Fronczek, Frank R., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., McChesney, James D., Rochford, Rosemary, Walker, Larry A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2014
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136050/
https://ncbi.nlm.nih.gov/pubmed/24913163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02674-13
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