Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes

BACKGROUND: The activity and haemolytic toxicity associated with primaquine has been linked to its reactive metabolites. The reactive metabolites are thought to be primarily formed through the action of cytochrome P(450)-mediated pathways. Human erythrocytes generally are not considered a significan...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Fasinu, Pius S., Nanayakkara, N. P. Dhammika, Wang, Yan-Hong, Chaurasiya, Narayan D., Herath, H. M. Bandara, McChesney, James D., Avula, Bharathi, Khan, Ikhlas, Tekwani, Babu L., Walker, Larry A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352325/
https://ncbi.nlm.nih.gov/pubmed/30700282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-019-2658-5
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