Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry

BACKGROUND: Primaquine (PQ), an 8-aminoquinoline, is the only drug approved by the United States Food and Drug Administration for radical cure and prevention of relapse in Plasmodium vivax infections. Knowledge of the metabolism of PQ is critical for understanding the therapeutic efficacy and hemoly...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Avula, Bharathi, Tekwani, Babu L., Chaurasiya, Narayan D., Fasinu, Pius, Dhammika Nanayakkara, N. P., Bhandara Herath, H. M. T., Wang, Yan-Hong, Bae, Ji-Yeong, Khan, Shabana I., Elsohly, Mahmoud A., McChesney, James D., Zimmerman, Peter A., Khan, Ikhlas A., Walker, Larry A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090659/
https://ncbi.nlm.nih.gov/pubmed/30103751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-018-2433-z
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