Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry

BACKGROUND: Primaquine (PQ), an 8-aminoquinoline, is the only drug approved by the United States Food and Drug Administration for radical cure and prevention of relapse in Plasmodium vivax infections. Knowledge of the metabolism of PQ is critical for understanding the therapeutic efficacy and hemoly...

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Dettagli Bibliografici
Pubblicato in:Malar J
Autori principali: Avula, Bharathi, Tekwani, Babu L., Chaurasiya, Narayan D., Fasinu, Pius, Dhammika Nanayakkara, N. P., Bhandara Herath, H. M. T., Wang, Yan-Hong, Bae, Ji-Yeong, Khan, Shabana I., Elsohly, Mahmoud A., McChesney, James D., Zimmerman, Peter A., Khan, Ikhlas A., Walker, Larry A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6090659/
https://ncbi.nlm.nih.gov/pubmed/30103751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-018-2433-z
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