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Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study

The method for the determination of primaquine (PQ) and 5,6-orthoquinone primaquine (5,6-PQ), the representative marker for PQ active metabolites, via CYP2D6 in human plasma and urine has been validated. All samples were extracted using acetonitrile for protein precipitation and analyzed using the u...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Pookmanee, Waritda, Thongthip, Siriwan, Tankanitlert, Jeeranut, Mungthin, Mathirut, Sukasem, Chonlaphat, Wittayalertpanya, Supeecha
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8304466/
https://ncbi.nlm.nih.gov/pubmed/34299634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26144357
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