CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

BACKGROUND: The naturally occurring alkaloid drug, quinine is commonly used for the treatment of severe malaria. Despite centuries of use, its metabolism is still not fully understood, and may play a role in the haemolytic disorders associated with the drug. METHODS: Incubations of quinine with CYPs...

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Detalhes bibliográficos
Main Authors: Marcsisin, Sean R, Jin, Xiannu, Bettger, Theresa, McCulley, Nicholas, Sousa, Jason C, Shanks, G Dennis, Tekwani, Babu L, Sahu, Rajnish, Reichard, Gregory A, Sciotti, Richard J, Melendez, Victor, Pybus, Brandon S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693902/
https://ncbi.nlm.nih.gov/pubmed/23800033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-12-214
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