The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

BACKGROUND: The efficacy of the 8-aminoquinoline (8AQ) drug primaquine (PQ) has been historically linked to CYP-mediated metabolism. Although to date no clear evidence exists in the literature that unambiguously assigns the metabolic pathway or specific metabolites necessary for activity, recent lit...

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Detalhes bibliográficos
Main Authors: Pybus, Brandon S, Marcsisin, Sean R, Jin, Xiannu, Deye, Gregory, Sousa, Jason C, Li, Qigui, Caridha, Diana, Zeng, Qiang, Reichard, Gregory A, Ockenhouse, Christian, Bennett, Jason, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689079/
https://ncbi.nlm.nih.gov/pubmed/23782898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-12-212
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