Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials

The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for prevention and treatment of malaria. Previously we...

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Publicado no:J Med Chem
Main Authors: Kancharla, Papireddy, Dodean, Rozalia A., Li, Yuexin, Pou, Sovitj, Pybus, Brandon, Melendez, Victor, Read, Lisa, Bane, Charles E., Vesely, Brian, Kreishman-Deitrick, Mara, Black, Chad, Li, Qigui, Sciotti, Richard J., Olmeda, Raul, Luong, Thu-Lan, Gaona, Heather, Potter, Brittney, Sousa, Jason, Marcsisin, Sean, Caridha, Diana, Xie, Lisa, Vuong, Chau, Zeng, Qiang, Zhang, Jing, Zhang, Ping, Lin, Hsiuling, Butler, Kirk, Roncal, Norma, Gaynor-Ohnstad, Lacy, Leed, Susan E., Nolan, Christina, Ceja, Frida G., Rasmussen, Stephanie A., Tumwebaze, Patrick K., Rosenthal, Philip J., Mu, Jianbing, Bayles, Brett R., Cooper, Roland A., Reynolds, Kevin A., Smilkstein, Martin J., Riscoe, Michael K., Kelly, Jane X.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354843/
https://ncbi.nlm.nih.gov/pubmed/32390431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00539
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