Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials

Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual stage activity against both liver stage and blood st...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Dodean, Rozalia A., Kancharla, Papireddy, Li, Yuexin, Melendez, Victor, Read, Lisa, Bane, Charles E., Vesely, Brian, Kreishman-Deitrick, Mara, Black, Chad, Li, Qigui, Sciotti, Richard J., Olmeda, Raul, Luong, Thu-Lan, Gaona, Heather, Potter, Brittney, Sousa, Jason, Marcsisin, Sean, Caridha, Diana, Xie, Lisa, Vuong, Chau, Zeng, Qiang, Zhang, Jing, Zhang, Ping, Lin, Hsiuling, Butler, Kirk, Roncal, Norma, Gaynor-Ohnstad, Lacy, Leed, Susan E., Nolan, Christina, Huezo, Stephanie J., Rasmussen, Stephanie A., Stephens, Melissa T., Tan, John C., Cooper, Roland A., Smilkstein, Martin J., Pou, Sovitj, Winter, Rolf W., Riscoe, Michael K., Kelly, Jane X.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6822569/
https://ncbi.nlm.nih.gov/pubmed/30852885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01961
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