Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

ELQ-300 is a preclinical antimalarial drug candidate that is active against liver, blood, and transmission stages of Plasmodium falciparum. While ELQ-300 is highly effective when administered in a low multi-dose regimen, poor aqueous solubility and high crystallinity have hindered its clinical devel...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:ACS Infect Dis
Päätekijät: Frueh, Lisa, LI, Yuexin, Mather, Michael W., Li, Qigui, Pou, Sovitj, Nilsen, Aaron, Winter, Rolf W., Forquer, Isaac P., Pershing, April M., Xie, Lisa H., Smilkstein, Martin J., Caridha, Diana, Campbell, Robert F., Sciotti, Richard J., Kreishman-Deitrick, Mara, Kelly, Jane X., Vesely, Brian, Vaidya, Akhil B., Riscoe, Michael K
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947850/
https://ncbi.nlm.nih.gov/pubmed/28927276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00062
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