Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems

To improve the solubility and oral bioavailability of a novel antimalarial agent ELQ-331 (a prodrug of ELQ-300), spray-dried dispersions (SDD) and a self-emulsifying drug delivery system (SEDDS) were developed. Spray-dried dispersions were prepared with polyvinyl caprolactam-polyvinyl acetate-polyet...

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Bibliografiska uppgifter
I publikationen:Pharm Dev Technol
Huvudupphovsmän: Potharaju, Suresh, Mutyam, Shravan Kumar, Liu, Mingtao, Green, Carol, Frueh, Lisa, Nilsen, Aaron, Pou, Sovitj, Winter, Rolf, Riscoe, Michael K., Shankar, Gita
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120996/
https://ncbi.nlm.nih.gov/pubmed/32031478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10837450.2020.1725893
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