Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts

Toxoplasmosis is a potentially fatal infection for immunocompromised people and the developing fetus. Current medicines for toxoplasmosis have high rates of adverse effects that interfere with therapeutic and prophylactic regimens. Endochin-like quinolones (ELQs) are potent inhibitors of Toxoplasma...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Doggett, J. Stone, Schultz, Tracey, Miller, Alyssa J., Bruzual, Igor, Pou, Sovitj, Winter, Rolf, Dodean, Rozalia, Zakharov, Lev N., Nilsen, Aaron, Riscoe, Michael K., Carruthers, Vern B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449172/
https://ncbi.nlm.nih.gov/pubmed/32540978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00535-20
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