Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice

We report on the efficacy of selected endochin-like quinolones (ELQs) against N. caninum tachyzoites grown in human foreskin fibroblasts (HFF), and in a pregnant BALB/c mouse model. Fourteen ELQs were screened against transgenic N. caninum tachyzoites expressing β-galactosidase (Nc-βgal). Drugs were...

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Vydáno v:Front Vet Sci
Hlavní autoři: Anghel, Nicoleta, Balmer, Vreni, Müller, Joachim, Winzer, Pablo, Aguado-Martinez, Adriana, Roozbehani, Mona, Pou, Sovitj, Nilsen, Aaron, Riscoe, Michael, Doggett, J. Stone, Hemphill, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Veterinary Science
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6252379/
https://ncbi.nlm.nih.gov/pubmed/30510935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fvets.2018.00285
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