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Acridones are Highly Potent Inhibitors of Toxoplasma gondii Tachyzoites
Acridone derivatives, which have been shown to have in vitro and in vivo activity against Plasmodium spp, inhibit Toxoplasma gondii proliferation at picomolar concentrations. Using enzymatic assays, we show that acridones inhibit both T. gondii cytochrome bc(1) and dihydroorotate dehydrogenase and i...
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| Publicado no: | ACS Infect Dis |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8273083/ https://ncbi.nlm.nih.gov/pubmed/33723998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.1c00016 |
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