Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials

The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for prevention and treatment of malaria. Previously we...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Med Chem
المؤلفون الرئيسيون: Kancharla, Papireddy, Dodean, Rozalia A., Li, Yuexin, Pou, Sovitj, Pybus, Brandon, Melendez, Victor, Read, Lisa, Bane, Charles E., Vesely, Brian, Kreishman-Deitrick, Mara, Black, Chad, Li, Qigui, Sciotti, Richard J., Olmeda, Raul, Luong, Thu-Lan, Gaona, Heather, Potter, Brittney, Sousa, Jason, Marcsisin, Sean, Caridha, Diana, Xie, Lisa, Vuong, Chau, Zeng, Qiang, Zhang, Jing, Zhang, Ping, Lin, Hsiuling, Butler, Kirk, Roncal, Norma, Gaynor-Ohnstad, Lacy, Leed, Susan E., Nolan, Christina, Ceja, Frida G., Rasmussen, Stephanie A., Tumwebaze, Patrick K., Rosenthal, Philip J., Mu, Jianbing, Bayles, Brett R., Cooper, Roland A., Reynolds, Kevin A., Smilkstein, Martin J., Riscoe, Michael K., Kelly, Jane X.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2020
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354843/
https://ncbi.nlm.nih.gov/pubmed/32390431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00539
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