Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs

Por Wickham, Kristina S., Baresel, Paul C., Marcsisin, Sean R., Sousa, Jason, Vuong, Chau T., Reichard, Gregory A., Campo, Brice, Tekwani, Babu L., Walker, Larry A., Rochford, Rosemary
Publicado no Antimicrob Agents Chemother (2016)

CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

Por Marcsisin, Sean R, Jin, Xiannu, Bettger, Theresa, McCulley, Nicholas, Sousa, Jason C, Shanks, G Dennis, Tekwani, Babu L, Sahu, Rajnish, Reichard, Gregory A, Sciotti, Richard J, Melendez, Victor, Pybus, Brandon S
Publicado em 2013

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

Por Pybus, Brandon S, Marcsisin, Sean R, Jin, Xiannu, Deye, Gregory, Sousa, Jason C, Li, Qigui, Caridha, Diana, Zeng, Qiang, Reichard, Gregory A, Ockenhouse, Christian, Bennett, Jason, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Publicado em 2013

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

Por Pybus Brandon S, Sousa Jason C, Jin Xiannu, Ferguson James A, Christian Robert E, Barnhart Rebecca, Vuong Chau, Sciotti Richard J, Reichard Gregory A, Kozar Michael P, Walker Larry A, Ohrt Colin, Melendez Victor
Publicado em 2012-08-01

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

Por Pybus, Brandon S, Sousa, Jason C, Jin, Xiannu, Ferguson, James A, Christian, Robert E, Barnhart, Rebecca, Vuong, Chau, Sciotti, Richard J, Reichard, Gregory A, Kozar, Michael P, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Publicado em 2012

Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes

Por Fasinu, Pius S., Avula, Bharathi, Tekwani, Babu L., Nanayakkara, N. P. Dhammika, Wang, Yan-Hong, Bandara Herath, H. M. T., McChesney, James D., Reichard, Gregory A., Marcsisin, Sean R., Elsohly, Mahmoud A., Khan, Shabana I., Khan, Ikhlas A., Walker, Larry A.
Publicado no Malar J (2016)

Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants

Por Jin, Xiannu, Potter, Brittney, Luong, Thu-lan, Nelson, Jennifer, Vuong, Chau, Potter, Corttney, Xie, Lisa, Zhang, Jing, Zhang, Ping, Sousa, Jason, Li, Qigui, Pybus, Brandon S., Kreishman-Deitrick, Mara, Hickman, Mark, Smith, Philip L., Paris, Robert, Reichard, Gregory, Marcsisin, Sean R.
Publicado no Malar J (2016)

Enantioselective metabolism of primaquine by human CYP2D6

Por Fasinu, Pius S, Tekwani, Babu L, Nanayakkara, NP Dhammika, Avula, Bharathi, Herath, HMT Bandara, Wang, Yan-Hong, Adelli, Vijender R, Elsohly, Mahmoud A, Khan, Shabana I, Khan, Ikhlas A, Pybus, Brandon S, Marcsisin, Sean R, Reichard, Gregory A, McChesney, James D, Walker, Larry A
Publicado no Malar J (2014)

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers

Por Nanayakkara, N. P. Dhammika, Tekwani, Babu L., Herath, H. M. T. Bandara, Sahu, Rajnish, Gettayacamin, Montip, Tungtaeng, Anchalee, van Gessel, Yvonne, Baresel, Paul, Wickham, Kristina S., Bartlett, Marilyn S., Fronczek, Frank R., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., McChesney, James D., Rochford, Rosemary, Walker, Larry A.
Publicado em 2014

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

Por Marcsisin, Sean R, Sousa, Jason C, Reichard, Gregory A, Caridha, Diana, Zeng, Qiang, Roncal, Norma, McNulty, Ronan, Careagabarja, Julio, Sciotti, Richard J, Bennett, Jason W, Zottig, Victor E, Deye, Gregory, Li, Qigui, Read, Lisa, Hickman, Mark, Nanayakkara, N P Dhammika, Walker, Larry A, Smith, Bryan, Melendez, Victor, Pybus, Brandon S
Publicado em 2014

Differential Cytochrome P450 2D Metabolism Alters Tafenoquine Pharmacokinetics

Por Vuong, Chau, Xie, Lisa H., Potter, Brittney M. J., Zhang, Jing, Zhang, Ping, Duan, Dehui, Nolan, Christina K., Sciotti, Richard J., Zottig, Victor E., Nanayakkara, N. P. Dhammika, Tekwani, Babu L., Walker, Larry A., Smith, Philip L., Paris, Robert M., Read, Lisa T., Li, Qigui, Pybus, Brandon S., Sousa, Jason C., Reichard, Gregory A., Smith, Bryan, Marcsisin, Sean R.
Publicado no Antimicrob Agents Chemother (2015)

Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

Por Potter, Brittney M. J., Xie, Lisa H., Vuong, Chau, Zhang, Jing, Zhang, Ping, Duan, Dehui, Luong, Thu-Lan T., Bandara Herath, H. M. T., Dhammika Nanayakkara, N. P., Tekwani, Babu L., Walker, Larry A., Nolan, Christina K., Sciotti, Richard J., Zottig, Victor E., Smith, Philip L., Paris, Robert M., Read, Lisa T., Li, Qigui, Pybus, Brandon S., Sousa, Jason C., Reichard, Gregory A., Marcsisin, Sean R.
Publicado no Antimicrob Agents Chemother (2015)