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Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

Enzymes are classically proposed to accelerate reactions by binding substrates within active site environments that are structurally preorganized to optimize binding interactions with reaction transition states rather than ground states. This is a remarkably formidable task considering the limited 0...

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Bibliografiske detaljer
Main Authors: Sigala, Paul A., Kraut, Daniel A., Caaveiro, Jose M. M., Pybus, Brandon, Ruben, Eliza A., Ringe, Dagmar, Petsko, Gregory A., Herschlag, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700827/
https://ncbi.nlm.nih.gov/pubmed/18808119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja803928m
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