The troponin T isoform shift may constitute a protective compensatory mechanism in hypertrophic cardiomyopathy.

Por Sirpal, Sanjeev, Potter, James D.
Publicado no J Biol Chem (2015)

Challenging Current Paradigms Related to Cardiomyopathies: ARE CHANGES IN THE Ca(2+) SENSITIVITY OF MYOFILAMENTS CONTAINING CARDIAC TROPONIN C MUTATIONS (G159D AND L29Q) GOOD PRE...

Por Dweck, David, Hus, Nir, Potter, James D.
Publicado em 2008

Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts – role of myofilament Ca(2+) sensitivity increase

Por Sirenko, Syevda G, Potter, James D, Knollmann, Björn C
Publicado em 2006

Cardiac Troponin Mutations and Restrictive Cardiomyopathy

Por Parvatiyar, Michelle S., Pinto, Jose Renato, Dweck, David, Potter, James D.
Publicado em 2010

Predicting Cardiomyopathic Phenotypes by Altering Ca(2+) Affinity of Cardiac Troponin C

Por Parvatiyar, Michelle S., Pinto, Jose Renato, Liang, Jingsheng, Potter, James D.
Publicado em 2010

A Dilated Cardiomyopathy Troponin C Mutation Lowers Contractile Force by Reducing Strong Myosin-Actin Binding

Por Dweck, David, Reynaldo, Daniel P., Pinto, Jose R., Potter, James D.
Publicado em 2010

Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin

Por Chang, Audrey N., Greenfield, Norma J., Singh, Abhishek, Potter, James D., Pinto, Jose R.
Publicado no Front Physiol (2014)

A Functional and Structural Study of Troponin C Mutations Related to Hypertrophic Cardiomyopathy

Por Pinto, Jose Renato, Parvatiyar, Michelle S., Jones, Michelle A., Liang, Jingsheng, Ackerman, Michael J., Potter, James D.
Publicado em 2009

Functional Effects of a Restrictive Cardiomyopathy linked Cardiac Troponin I mutation (R145W) in Transgenic Mice

Por Wen, Yuhui, Xu, Yuanyuan, Wang, Yingcai, Pinto, Jose Renato, Potter, James D., Kerrick, W. Glenn L.
Publicado em 2009

A Mutation in TNNC1-encoded Cardiac Troponin C, TNNC1-A31S, Predisposes to Hypertrophic Cardiomyopathy and Ventricular Fibrillation

Por Parvatiyar, Michelle S., Landstrom, Andrew P., Figueiredo-Freitas, Cicero, Potter, James D., Ackerman, Michael J., Pinto, Jose Renato
Publicado em 2012

The Functional Properties of Human Slow Skeletal Troponin T Isoforms in Cardiac Muscle Regulation

Por Pinto, Jose Renato, Gomes, Aldrin V., Jones, Michelle A., Liang, Jingsheng, Nguyen, Susan, Miller, Todd, Parvatiyar, Michelle S., Potter, James D.
Publicado em 2012

Functional Consequences of the Human Cardiac Troponin I Hypertrophic Cardiomyopathy Mutation R145G in Transgenic Mice

Por Wen, Yuhui, Pinto, Jose Renato, Gomes, Aldrin V., Xu, Yuanyuan, Wang, Yingcai, Wang, Ying, Potter, James D., Kerrick, W. Glenn L.
Publicado em 2008

Myofilament Ca(2+) sensitization causes susceptibility to cardiac arrhythmia in mice

Por Baudenbacher, Franz, Schober, Tilmann, Pinto, Jose Renato, Sidorov, Veniamin Y., Hilliard, Fredrick, Solaro, R. John, Potter, James D., Knollmann, Björn C.
Publicado em 2008

Strong Cross-bridges Potentiate the Ca(2+) Affinity Changes Produced by Hypertrophic Cardiomyopathy Cardiac Troponin C Mutants in Myofilaments: A FAST KINETIC APPROACH

Por Pinto, Jose Renato, Reynaldo, Daniel P., Parvatiyar, Michelle S., Dweck, David, Liang, Jingsheng, Jones, Michelle A., Sorenson, Martha M., Potter, James D.
Publicado em 2011

Functional Characterization of TNNC1 Rare Variants Identified in Dilated Cardiomyopathy

Por Pinto, Jose Renato, Siegfried, Jill D., Parvatiyar, Michelle S., Li, Duanxiang, Norton, Nadine, Jones, Michelle A., Liang, Jingsheng, Potter, James D., Hershberger, Ray E.
Publicado em 2011

Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy

Por Wang, Yingcai, Pinto, Jose Renato, Solis, Raquel Sancho, Dweck, David, Liang, Jingsheng, Diaz-Perez, Zoraida, Ge, Ying, Walker, Jeffery W., Potter, James D.
Publicado em 2012

Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy

Por Hershberger, Ray E., Pinto, Jose Renato, Parks, Sharie B., Kushner, Jessica D., Li, Duanxiang, Ludwigsen, Susan, Cowan, Jason, Morales, Ana, Parvatiyar, Michelle S., Potter, James D.
Publicado em 2009

Late Onset Sporadic Dilated Cardiomyopathy Caused by a Cardiac Troponin T Mutation

Por Morales, Ana, Pinto, Jose Renato, Siegfried, Jill D., Li, Duanxiang, Norton, Nadine, Hofmeyer, Mark, Vallin, Marta, Morales, Azorides R., Potter, James D., Hershberger, Ray E.
Publicado em 2010

Molecular and Functional Characterization of Novel Hypertrophic Cardiomyopathy Susceptibility Mutations in TNNC1- Encoded Troponin C

Por Landstrom, Andrew P., Parvatiyar, Michelle S., Pinto, Jose R., Marquardt, Michelle L., Bos, J. Martijn, Tester, David J., Ommen, Steve R., Potter, James D., Ackerman, Michael J.
Publicado em 2008

Noncanonical EF-hand motif strategically delays Ca(2+) buffering to enhance cardiac performance

Por Wang, Wang, Barnabei, Matthew S, Asp, Michelle L, Heinis, Frazer I, Arden, Erik, Davis, Jennifer, Braunlin, Elizabeth, Li, Qi, Davis, Jonathan P, Potter, James D, Metzger, Joseph M
Publicado em 2013