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Predicting Cardiomyopathic Phenotypes by Altering Ca(2+) Affinity of Cardiac Troponin C

Cardiac diseases associated with mutations in troponin subunits include hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Altered calcium handling in these diseases is evidenced by changes in the Ca(2+) sensitivity of contraction. Mutations in the...

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Autori principali: Parvatiyar, Michelle S., Pinto, Jose Renato, Liang, Jingsheng, Potter, James D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934646/
https://ncbi.nlm.nih.gov/pubmed/20566645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112326
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