Strong Cross-bridges Potentiate the Ca(2+) Affinity Changes Produced by Hypertrophic Cardiomyopathy Cardiac Troponin C Mutants in Myofilaments: A FAST KINETIC APPROACH

This spectroscopic study examined the steady-state and kinetic parameters governing the cross-bridge effect on the increased Ca(2+) affinity of hypertrophic cardiomyopathy-cardiac troponin C (HCM-cTnC) mutants. Previously, we found that incorporation of the A8V and D145E HCM-cTnC mutants, but not E1...

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Hlavní autoři: Pinto, Jose Renato, Reynaldo, Daniel P., Parvatiyar, Michelle S., Dweck, David, Liang, Jingsheng, Jones, Michelle A., Sorenson, Martha M., Potter, James D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020707/
https://ncbi.nlm.nih.gov/pubmed/21056975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.168583
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