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Pathogenesis Associated with a Restrictive Cardiomyopathy Mutant in Cardiac Troponin T is Due to Reduced Protein Stability and Greatly Increased Myofilament Ca(2+) Sensitivity
BACKGROUND: Dilated and hypertrophic cardiomyopathy mutations in troponin can blunt effects of protein kinase A (PKA) phosphorylation of cardiac troponin I (cTnI), decreasing myofilament Ca(2+)-sensitivity; however this effect has never been tested for restrictive cardiomyopathy (RCM) mutants. This...
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| Publicado en: | Biochim Biophys Acta |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4276470/ https://ncbi.nlm.nih.gov/pubmed/25450489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2014.09.029 |
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