Pathogenic Troponin T Mutants with Opposing Effects on Myofilament Ca(2+) Sensitivity Attenuate Cardiomyopathy Phenotypes in Mice

Mutations in cardiac troponin T (TnT) associated with hypertrophic cardiomyopathy generally lead to an increase in the Ca(2+) sensitivity of contraction and susceptibility to arrhythmias. In contrast, TnT mutations linked to dilated cardiomyopathy decrease the Ca(2+) sensitivity of contraction. Here...

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Publicado no:Arch Biochem Biophys
Main Authors: Jones, Karissa M. Dieseldorff, Koh, Yeojung, Weller, Rebecca S., Turna, Rajdeep S., Ahmad, Ferhaan, Huke, Sabine, Knollmann, Björn C., Pinto, Jose Renato, Hwang, Hyun Seok
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347385/
https://ncbi.nlm.nih.gov/pubmed/30445044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2018.11.006
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