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Pathogenic Troponin T Mutants with Opposing Effects on Myofilament Ca(2+) Sensitivity Attenuate Cardiomyopathy Phenotypes in Mice
Mutations in cardiac troponin T (TnT) associated with hypertrophic cardiomyopathy generally lead to an increase in the Ca(2+) sensitivity of contraction and susceptibility to arrhythmias. In contrast, TnT mutations linked to dilated cardiomyopathy decrease the Ca(2+) sensitivity of contraction. Here...
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| Publicat a: | Arch Biochem Biophys |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6347385/ https://ncbi.nlm.nih.gov/pubmed/30445044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2018.11.006 |
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