Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia

Por Steele, Derek S., Hwang, Hyun-Seok, Knollmann, Björn C.
Publicado em 2013

Accelerated junctional rhythm and non-alternans repolarization lability precede ventricular tachycardia in Casq2−/− mice

Por Mezu, Ure, Singh, Prabhpreet, Shusterman, Vladimir, Hwang, Hyun Seok, Knollmann, Bjorn C., Němec, Jan
Publicado em 2012

Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload

Por Hwang, Hyun Seok, Baldo, Marcelo P., Rodriguez, Jose Pindado, Faggioni, Michela, Knollmann, Bjorn C.
Publicado no Front Physiol (2019)

Parameter Sensitivity Analysis of Stochastic Models Provides Insights into Cardiac Calcium Sparks

Por Lee, Young-Seon, Liu, Ona Z., Hwang, Hyun Seok, Knollmann, Bjorn C., Sobie, Eric A.
Publicado em 2013

Inhibition of Cardiac Ca(2+) Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia

Por Hwang, Hyun Seok, Hasdemir, Can, Laver, Derek, Mehra, Divya, Turhan, Kutsal, Faggioni, Michela, Yin, Huiyong, Knollmann, Björn C.
Publicado em 2011

Suppression of Spontaneous Ca Elevations Prevents Atrial Fibrillation in Casq2 Null Hearts

Por Faggioni, Michela, Savio-Galimberti, Eleonora, Venkataraman, Raghav, Hwang, Hyun-Seok, Kannankeril, Prince J., Darbar, Dawood, Knollmann, Björn C.
Publicado em 2014

Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis and causes pause-dependent Ca triggered arrhythmia

Por Schober, Tilmann, Huke, Sabine, Venkataraman, Raghav, Gryshchenko, Oleksiy, Kryshtal, Dmytro, Hwang, Hyun-Seok, Baudenbacher, Franz J., Knollmann, Björn C.
Publicado em 2012

Myofilament calcium de-sensitization and contractile uncoupling prevents pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction

Por Venkataraman, Raghav, Baldo, Marcelo Perim, Hwang, Hyun-Seok, Veltri, Tiago, Pinto, Jose Renato, Baudenbacher, Franz J., Knollmann, Bjorn C.
Publicado em 2013

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

Por Salazar, Gloria, Cullen, Abigail, Huang, Jingwen, Zhao, Yitong, Serino, Alexa, Hilenski, Lula, Patrushev, Nikolay, Forouzandeh, Farshad, Hwang, Hyun Seok
Publicado no Autophagy (2019)

Functional consequences of stably expressing a mutant calsequestrin (CASQ2(D307H)) in the CASQ2 null background

Por Kalyanasundaram, Anuradha, Viatchenko-Karpinski, Serge, Belevych, Andriy E., Lacombe, Veronique A., Hwang, Hyun Seok, Knollmann, Björn C., Gyorke, Sandor, Periasamy, Muthu
Publicado em 2012

Accelerated Sinus Rhythm Prevents Catecholaminergic Polymorphic Ventricular Tachycardia in Mice and in Patients

Por Faggioni, Michela, Hwang, Hyun Seok, van der Werf, Christian, Nederend, Ineke, Kannankeril, Prince J., Wilde, Arthur A.M., Knollmann, Björn C.
Publicado em 2013

Coordinated Regulation of Murine Cardiomyocyte Contractility by Nanomolar (−)-Epigallocatechin-3-Gallate, the Major Green Tea Catechin

Por Feng, Wei, Hwang, Hyun Seok, Kryshtal, Dmytro O., Yang, Tao, Padilla, Isela T., Tiwary, Asheesh K., Puschner, Birgit, Pessah, Isaac N., Knollmann, Björn C.
Publicado em 2012

Pathogenic Troponin T Mutants with Opposing Effects on Myofilament Ca(2+) Sensitivity Attenuate Cardiomyopathy Phenotypes in Mice

Por Jones, Karissa M. Dieseldorff, Koh, Yeojung, Weller, Rebecca S., Turna, Rajdeep S., Ahmad, Ferhaan, Huke, Sabine, Knollmann, Björn C., Pinto, Jose Renato, Hwang, Hyun Seok
Publicado no Arch Biochem Biophys (2018)

Comparable Calcium Handling Of Human iPSC-derived Cardiomyocytes Generated By Multiple Laboratories

Por Hwang, Hyun Seok, Kryshtal, Dmytro O., Feaster, Tromondae K., Sánchez-Freire, Verónica, Zhang, Jianhua, Kamp, Timothy J., Hong, Charles C., Wu, Joseph C., Knollmann, Björn C.
Publicado no J Mol Cell Cardiol (2015)

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

Por Watanabe, Hiroshi, Chopra, Nagesh, Laver, Derek, Hwang, Hyun Seok, Davies, Sean S, Roach, Daniel E, Duff, Henry J, Roden, Dan M, Wilde, Arthur A M, Knollmann, Björn C
Publicado em 2009

Divergent Regulation of Ryr2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

Por Hwang, Hyun-Seok, Nitu, Florentin R, Yang, Yi, Walweel, Kafa, Pereira, Laetitia, Johnson, Christopher N, Faggioni, Michela, Chazin, Walter J, Laver, Derek, George, Alfred L, Cornea, Razvan L, Bers, Donald M, Knollmann, Björn C
Publicado em 2014

Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit...

Por Lee, Young Soo, Maruyama, Mitsunori, Chang, Po Cheng, Park, Hyung Wook, Rhee, Kyoung-Suk, Hsieh, Yu-Cheng, Hsueh, Chia-Hsiang, Shen, Changyu, Lin, Shien-Fong, Hwang, Hyun Seok, Yin, Huiyong, Knollmann, Björn C., Chen, Peng-Sheng
Publicado em 2012

Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin (CaM) Variants in Long QT Syndrome (LQTS) and Functional Characterization of a Novel LQTS-Associated CaM Mis...

Por Boczek, Nicole J., Gomez-Hurtado, Nieves, Ye, Dan, Calvert, Melissa L., Tester, David J., Kryshtal, Dmytro, Hwang, Hyun Seok, Johnson, Christopher N., Chazin, Walter J., Loporcaro, Christina G., Shah, Maully, Papez, Andrew L., Lau, Yung R., Kanter, Ronald, Knollmann, Bjorn C., Ackerman, Michael J.
Publicado no Circ Cardiovasc Genet (2016)