Suppression of Spontaneous Ca Elevations Prevents Atrial Fibrillation in Casq2 Null Hearts

BACKGROUND: Atrial fibrillation (AF) risk has been associated with “leaky” ryanodine receptor (RyR2) Ca release channels. Patients with mutations in RyR2 or in the sarcoplasmic reticulum Ca binding protein calsequestrin (Casq2) display an increased risk for AF. Here we examine the underlying mechani...

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Huvudupphovsmän: Faggioni, Michela, Savio-Galimberti, Eleonora, Venkataraman, Raghav, Hwang, Hyun-Seok, Kannankeril, Prince J., Darbar, Dawood, Knollmann, Björn C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989424/
https://ncbi.nlm.nih.gov/pubmed/24493699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.113.000994
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