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Suppression of Spontaneous Ca Elevations Prevents Atrial Fibrillation in Casq2 Null Hearts
BACKGROUND: Atrial fibrillation (AF) risk has been associated with “leaky” ryanodine receptor (RyR2) Ca release channels. Patients with mutations in RyR2 or in the sarcoplasmic reticulum Ca binding protein calsequestrin (Casq2) display an increased risk for AF. Here we examine the underlying mechani...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989424/ https://ncbi.nlm.nih.gov/pubmed/24493699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.113.000994 |
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