SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

Defective macroautophagy/autophagy and mitochondrial dysfunction are known to stimulate senescence. The mitochondrial regulator PPARGC1A (peroxisome proliferator activated receptor gamma, coactivator 1 alpha) regulates mitochondrial biogenesis, reducing senescence of vascular smooth muscle cells (VS...

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Publicat a:Autophagy
Autors principals: Salazar, Gloria, Cullen, Abigail, Huang, Jingwen, Zhao, Yitong, Serino, Alexa, Hilenski, Lula, Patrushev, Nikolay, Forouzandeh, Farshad, Hwang, Hyun Seok
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469683/
https://ncbi.nlm.nih.gov/pubmed/31441382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1659612
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